Study of the Influence of Cigarette Smoking on Serum Oxidant and Antioxidant Status

Abstract

The use of tobacco is a word wide problem and the traditional method of tobacco use is smoking cigarettes. This study was aimed to investigate the balance state in oxidation system (by measuring malondialdehyde (MDA) levels lipid peroxdation marker) - antioxidant system (by measuring ceruloplasmin (Cp) antioxidant marker) and attempted to shed a light on the possible correlation between (MDA), (Cp) and age of smokers and period of smoking.
Sample size was (49) healthy adult men smokers between the ages of 19-32. The results showed a presence of a significant increase in MDA levels in all smoker groups (P ≤ 0.05) in comparison with control group (nonsmokers). Also, the results evinced the presence of a significant decrease in ceruloplasmin levels (P ≤ 0.05) in comparison with control group (nonsmokers).
Our results confirmed the role of reactive oxygen species (ROS) in development of oxidative stress disorders, where serum MDA was found to be positively correlated with period of smoking. Whereas the results showed the presence a negative correlation between ceruloplasmin and period of smoking. Also proved no relationship between age of smokers and MDA levels and Cp levels.