SYNTHESIS , CHARACTERIZATION AND STUDY BIOLOGICAL ACTIVITY SOME NEW DERIVATIVES AMIDE AND PYRAZOLE –PYRAZOLINE OF STEROID ANALOGS .

  • Nabeel A.A.AL-Rida
  • Ali M. Farhan
DOI: https://doi.org/10.29350/jops.2019.24.3.971

Abstract

ABSTRACT

      The number of steroids and their derivatives possess divers pharmacological activities as drugs for the treatment of a large number of diseases so in this work was suggested prepared  two series amides and pyrazoles of steroid analogs ( methyl((5-pregnant-3β,17-diol-15-yl) thio) propanoate) .   Amides derivatives ( 6 - 9 ) prepared directionally after treated the steroid analogs with primary amine substituted in basic medium  .      Carbo hydrazide steroid derivative (10 ) was obtained by treated steroid analogs with hydrazine hydrate , this compound use as intermediate for synthesis Pyrazolin (13 )  as well as  Pyrazole (14) .

All the newly synthesized compounds have been identified by IR, 1H NMR, 13CNMR, 2D-NMR     ( HMBC , HSQC )  and C.H.N Analysis

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Published
2019-11-23
How to Cite
A.A.AL-Rida , N., & Farhan, A. M. (2019). SYNTHESIS , CHARACTERIZATION AND STUDY BIOLOGICAL ACTIVITY SOME NEW DERIVATIVES AMIDE AND PYRAZOLE –PYRAZOLINE OF STEROID ANALOGS . Al-Qadisiyah Journal of Pure Science, 24(3). https://doi.org/10.29350/jops.2019.24.3.971
Issue
Vol 24 No 3 (2019)
Section
Articles

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